BCA-CCP4 Summer School

Aug 21. till Aug 26.

BCA/CCP4 Summer School

A week long residential course, the BCA/CCP4 Protein Crystallography Summer School is intended to provide students and researchers with an introduction to crystallogra

Date
21/08/2016 - 26/08/2016
Location
Diamond Light Source, Oxfordshire, UK
URL
Apply here

BCA/CCP4 Summer School in Protein Crystallography

Sunday 21st August - Friday 26th August 2016

The BCA/CCP4 Protein Crystallography Summer School is intended for students and researchers new to crystallography. Its dual aims are to provide comprehensive training in crystallography and to promote best practise within the British crystallographic community. The lectures cover the gamut of techniques required for a structure solution, from protein expression through to structure validation. Intensively supervised computer tutorials enable students to relate the theory presented in the lectures to practice. Although CCP4 programmes will primarily be used in these tutorials, the aim will be to approach crystallographic questions in a software-agnostic manner. There will also be a crystal manipulation and cooling workshop. (Note that the course is scheduled during Diamond synchrotron downtime, so there will not be active data collection at the Diamond beamlines.)

Eligibility

Postgraduate students should have started their research degree in or before October 2013.

Other researchers with approximately 2 years of crystallographic experience are also eligible. All applicants will require a letter of support from their supervisor.

Cost

Registration fees for attendees are kept well below cost price thanks to substantial resources allocated to bursaries (including particular support for BBSRC funded researchers),a grant from CCP4 and generous donations from our sponsors.

The cost of the school, including full board, will be 250 GBP (includes VAT). 

Application

REGISTRATION IS NOW OPEN

Before beginning the application process please prepare your CV/resume including a description of your crystallographic experience, other skills, and why you want to attend the course. You should also confirm in advance that the person you nominate as your referee will support your application, because your referee will be sent an email automatically as soon as you submit your application.

Numbers are strictly limited to 40.  We will allocate places on the grounds of merit and anticipated benefit to the student.

Accepted Students will be required to undertake that they will attend the whole course (no late arrivals or early departures).

Venue

The course is residential, with accommodation provided at Ridgeway House at Diamond.

Lectures and tutorials will take place at Diamond.

The crystal manipulation and cooling workshop will be held at the Research Complex at Harwell (located next to the Diamond synchrotron).

Programme- BCA/CCP4 Protein Crystallography Summer School 2016

DOWNLOAD PROGRAMME HERE

Sunday 21st August 2016

15:00

 

Arrival and registration

16:00

 

Welcome

16:00

#1

Lecture: Protein Expression and Purification

Jane Endicott

16:30

 

Student Stories I

18:30

 

Dinner - Buffet

19:00

 

Student Stories II

21:00

#2

Lecture: Diffraction

Airlie McCoy

21:30

 

Drinks

Monday 22nd August 2016

7:30

 

Breakfast

9:00

#3

Lecture: Crystallization

Jane Endicott

9:45

#4

Lecture: Symmetry

Martin Noble

10:30

 

Coffee

11:00

#5

Lecture: Crystal Preparation for Cryocrystallography

Elspeth Garman

12:30

 

Lunch

Practical: Crystal Manipulation for Cryocrystallography

Group 1

Elspeth Garman

13:30

#6

Lecture: Data Collection

Katherine McAuley

14:30

#7

Lecture: Data Scaling and Merging

Frank von Delft

15:30

 

Tea

16:00

 

Bus to Oxford

17:00 -21:30

 

Cruise on the River Thames in a Salter’s steamer

 

Tuesday 23rd August 2016

7:30

 

Breakfast

9:00

#8

Practical: Data Processing

Leader: Ed Lowe

10:30

 

Coffee

11:00

#9

Lecture: Models for Molecular Replacement

Nick Keep

11:30

#10

Lecture: Molecular Replacement

Martin Noble/Airlie McCoy

12:30

 

Lunch

Practical: Crystal Manipulation for Cryocrystallography

Group 2

Elspeth Garman

13:30

#11

Practical: Molecular Replacement

Leaders: Nick Keep/Airlie McCoy

15:30

 

Tea

16:00

 

Tour of Ring  

17:30

#12

Demonstration: ccp4i2

Martin Noble

18:30

#13

Lecture: Data Management

Alun Ashton

19:00

 

Dinner

20:00

 

Guest Lecture

Wednesday 24th August 2016

7:45-8:30

 

Breakfast

9:00

#14

Lecture: Maximum likelihood with Dice

Airlie McCoy

9:45

#15

Lecture: Radiation Damage

Elspeth Garman

10:30

 

 Coffee

11:00

#16

Lecture: Preparation of Derivatives

Elspeth Garman

11:30

#17

Lecture: Finding Heavy Atom Sites/Pattersons

Martin Noble

12:00

#18

Lecture: Experimental Phasing MAD/SAD

Airlie McCoy

12.30

 

Lunch

Practical: Crystal Manipulation for Cryocrystallography

Group 3

Elspeth Garman

13:30

#19

Lecture: Phase Improvement and Model Building

Kevin Cowtan

15:00

 

Tea

15:30

#20

Practical: MAD/SAD Phasing

Leader: Martin Noble

17:30

#21

Quiz I

19:00

 

Dinner

20:00

 

Guest Lecture

Brian Sutton

Thursday 25th August 2016

7:30

 

Breakfast

9:00

#22

Lecture: Refinement

Nick Keep

10:30

 

Coffee

11:00

#23

Lecture: Validation

Swanand Gore

12:30

 

Lunch

Practical: Crystal Manipulation for Cryocrystallography

Group 4

Elspeth Garman

13:30

#24

Lecture: Graphics and Representations

Martin Noble

14:15

#25

Lecture: Twinning

Airlie McCoy

15:30

 

Tea

16:00

#26

Practical: Map Interpretation and MIR Phasing

Leader: Paul Emsley

19:30

 

Conference Dinner

Guest Speaker

Friday 26th August 2014

7:30

 

Breakfast

9:30

#27

Lecture: Complementing crystallography with other structural techniques

Nick Keep

11:00

 

Strong Coffee

11:30

#28

Quiz II

12:30

 

Close

Practical: Crystal Manipulation for Cryocrystallography

Group 5

Elspeth Garman

 

Social Programme

We recognise that the social programme plays a role in enabling students to make links that may be maintained throughout a research career. There will be a conference dinner, and a number of other events, including a boat trip on the Thames from Oxford.