eBIC is designed and operated in a similar way to a beamline at Diamond, namely through peer review open to UK, EU and international scientists. European users should now apply for access and support through the H2020 project i-NEXT and select the Diamond EM platform here. The facility is free at the point of access except for commercial use, or users requiring guaranteed access, such access should be arranged directly through the Industrial Liaison Office.
Access commenced in July 2015 through a peer-reviewed Rapid access route. We are now also introducing Peer reviewed Block Allocation Group (BAG) access, which transformed access to MX beamlines as it has provided a successful mechanism for research groups to apply for frequent and regular access for beamtime. This replaces the standard access route which provided a mechanism for one-off proposals to be submitted bi-annually.
Access for European users is funded through the Horizon 2020 iNEXT project which also uses the Rapid Access route. Users outside of the UK and Europe typically have to cover their own travel and subsistence costs.
The two modes of access to eBIC are described in more detail below.
Applications for Rapid Access should be made using the EM rapid access template.
Please note that the standard allocation period for rapid access is currently 2 days, unless a strong case is made for more time. This default period will be reviewed as eBIC matures.
Rapid proposals are welcome at any time although applications are accumulated until a deadline is reached when they are peer reviewed and a schedule drawn up. Deadlines for rapid access applications are every 3 months from 1st April 2016. We would hope to announce the result of an application, and inform successful applicants of the schedule within ~6 weeks of the deadline, so far heavy oversubscription and new processes have made this challenging. We expect this to improve as the facility builds up.
Applications should be made through the Diamond User Administration System and first applications for the BAG access route are being accepted in the current call (deadline 1st April 2016). The BAG access route will provide users with microscope time from October 2016 and is available to large institutions or sets of groups from different establishments who want regular access to the microscope. BAG proposals cover a 2-year period and there are two proposal call deadlines per year of the 1st April and 1st October. Time is awarded in 6-month intervals with the BAG users responsible for internally assigning groups to the allocated microscope time. Reporting and request for additional microscope time are made bi-annually coinciding with proposal deadline dates.
We expect to allocate at least 200 days of microscope time to the peer reviewed user programme during Oct 2016 – Mar 2017 of which up to 50% may be allocated to BAGS. In this first phase of implementation we do not expect to be able to establish more than 6 BAGs. If you are considering a BAG application we would suggest you contact Martin Walsh (email@example.com) ahead of the deadline since we anticipate heavy over-demand.
On the initial submission of a new proposal the user must supply the following details:
Applications should be made via the UAS and user should request the eBIC - Cryo-Electron Microscopy for Life Sciences. If awarded time then the proposal will be scheduled on the appropriate microscope at Diamond or OPIC (Krios 1 or Polara).
All proposals are awarded time based on scientific excellence and are subject to standard Diamond terms and conditions, notably that the work must be published. The proposal requires evidence of suitable cryo EM samples, specifically an image recorded on a cryo-EM that shows enough to be convincing to a referee is required.
Travel and subsistence is covered for UK users (normally 1-2 people per visit). Accommodation is at the onsite guest house or nearby.
Users publishing work containing data from eBIC should ensure they:
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