eBIC (electron Bio-Imaging Centre) at Diamond Light Source provides scientists with state-of-the-art experimental equipment and expertise in the field of cryo-electron microscopy, for single particle analysis and cryo-tomography.
Two powerful cryo-electron microscopes allow users to investigate the structure of individual cells and to visualise single bio-molecules, exploiting techniques that are rarely available at home laboratories.
Along with state-of-the-art facilities, the centre will provide training courses for structural and cell biologists, and remain cutting edge though strong, in-house research.
Techniques available on eBIC:
• Single particle analysis of biological macromolecules
• Cellular tomography
• Electron crystallography
Krios I welcomes first users from MRC LMB Cambridge
[Publication] A national facility for biological cryo-electron microscopy. Saibil, H. R., Grunewald, K. & Stuart, D. I. (2015). Acta Cryst. D 71, 127-135. DOI: 10.1107/S1399004714025280
eBIC was located at Diamond following the award of a £15.6 million grant from the Wellcome Trust, the Medical Research Council (MRC) and the Biotechnology and Biological Sciences Research Council (BBSRC).
This investment supports broad, cost-effective access to these specialised techniques. Increasingly, the combination of advanced methods is needed to understand biology at the molecular level; and so synergy with the other techniques offered by Diamond makes it an ideal location, where strong expertise and infrastructure are already in place.
The location of eBIC also means that scientists can combine their techniques with many of the other cutting-edge approaches that Diamond offers; whilst a partnership with Polara – a high-containment cryo-electron microscope based at the University of Oxford – ensures that users have access to the broadest possible range of advanced techniques.
The eBIC building is due for completion early 2016. In the meantime, users are able to access two of the associated microscopes: Polara at the University of Oxford, and Krios I at Diamond.
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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